Rare Cardiotoxicity in a Child Following Accidental Alphachloralose Ingestion: A Case Study with In-Silico Insights

Abstract

Cardiotoxicity associated with alphachloralose is poorly understood, and its underlying mechanisms remain unclear. Only a few cases have been reported in the literature. We present the case of a 5-year-old child who experienced moderate alphachloralose poisoning following accidental ingestion. Cardiac involvement was identified through elevated troponin levels, with a favorable outcome following symptomatic treatment. The interaction between alphachloralose and cardiotoxicity was evaluated using in silico methods. Alphachloralose potentially induces cardiotoxicity through 15 key overlapping targets, including STAT3, MMP2, and CASP3, identified via database integration and correlation analysis. STAT3, MMP2, and CASP3 emerge as critical targets in alphachloralose-induced cardiotoxicity, offering potential avenues for therapeutic intervention.